Content

  1. Curated Burkholderia mallei (strain ATCC 23344) and Burkholderia pseudomallei (strain K96243) proteins (>400) associated with 5 secretion systems and 13 inferred pathogen mechanisms of action
  2. Host-pathogen protein-protein interactions (>4,400)

Application

  1. Proteins
    • Input: Protein (pathogen or host)
    • Output: Detailed protein annotation
  2. Secretion Systems
    • Input: Secretion system type and pathogen
    • Output: Pathogen proteins associated with the secretion system
  3. Mechanisms of Action
    • Input: Biological mechanism of action and pathogen
    • Output: Pathogen proteins associated with the mechanism of action
  4. Host-pathogen Protein Interactions
    • Input: Host and pathogen
    • Output: List of host-pathogen protein-protein interactions
  5. Virulence Attenuation (by genetic ablation)
    • Input: Pathogen
    • Output: Experimental validation of putative virulence factors

References:

  1. Memišević, V., K. Kumar, N. Zavaljevski, D. DeShazer, A. Wallqvist, and J. Reifman. DBSecSys 2.0: A database of Burkholderia mallei and Burkholderia pseudomallei secretion systems. BMC Bioinformatics (2016), 17:387.(PubMed ID: 27650316)
  2. Memišević, V., K. Kumar, L. Cheng, N. Zavaljevski, D. DeShazer, A. Wallqvist, and J. Reifman. DBSecSys: A Database of Burkholderia mallei secretion systems. BMC Bioinformatics (2014), 15:244.(PubMed ID: 25030112)
  3. Memišević, V., N. Zavaljevski, R. Pieper, S. V. Rajagopala, K. Kwon, K. Townsend, C. Yu, X. Yu, D. DeShazer, J. Reifman, and A. Wallqvist. Novel Burkholderia mallei virulence factors linked to specific host-pathogen protein interactions. Molecular & Cellular Proteomics (2013), 12(11):3036-51.(PubMed ID: 23800426)
  4. Memišević, V., N. Zavaljevski, S. V. Rajagopala, K. Kwon, R. Pieper, D. DeShazer, J. Reifman, and A. Wallqvist. Mining host-pathogen protein interactions to characterize Burkholderia mallei infectivity mechanisms. PLOS Computational Biology. 2015 March 4; 11(3):e1004088.(PubMed ID: 23800426)